【摘 要】
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A tuberculosis (TB) susceptibility locus was previously located on chromosome 11p15.Since IFITM3 is located at 11p15, is an effector molecule for interferons, and can disrupt viral replication via the
【机 构】
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Key Laboratory of Major Diseases in Children and National, Key Discipline of Pediatrics (Capital Med
【出 处】
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首都医科大学2013年研究生学术论坛
论文部分内容阅读
A tuberculosis (TB) susceptibility locus was previously located on chromosome 11p15.Since IFITM3 is located at 11p15, is an effector molecule for interferons, and can disrupt viral replication via the endo-lysosome pathway, our initial aim was to investigate associations between susceptibility to TB in Han Chinese children and genetic polymorphisms of the IFITM3 core promoter.Our second aim was to elucidate the effect of the TB-associated genotypes variations on both the baseline and IFN-γ induced IFITM3 expression.
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