Nanoseience and nanotechnology are rapidly changing the daily life of the human being in the global economy.In particular, nano-mechanics and materials are playing an increasingly important role in biological and biomedical applications, such as biocompatible implant materials and novel materials for drug delivery.This new generation of bio materials has unique structures and properties and could revolutionize not only the medical practice in particular but also the life science and engineering in general.Over the last several years, we have conducted a number of researches in different areas ofnano-and bio-mechanics and materials.In the first part of this talk, several new achievements made in the area of nano-mechanics will be reported.