论文部分内容阅读
海洋吡咯类生物碱Ningalin B类似物的设计合
【机 构】
:
中国海洋大学医药学院;海洋药物教育部重点实验室;山东省糖科学与糖工程重点实验室
【出 处】
:
全国药物化学学术会议暨第四届中英药物化学学术会议
【发表日期】
:
2013年11期
其他文献
When we consider molecular structure,we usually think about a molecules bonded structure in 2D or 3D.However,the protein active site sees only the overall shape of the molecule and its chemical featur
会议
Library construction of bioactive kaurane-type diterpenoid derivatives and their anti-tumor mechanis
会议
Acetylcholinesterase inhibitors are the most frequently prescribed anti-Alzheimers drugs.A series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives as the dual binding site acetylcholinesterase in
In the past 10 years,over 490 clinical trials of more than 20 HDACs inhibitors(HDACIs)candidates have been initiated,culminating in the approval of three anti-tumor drugs vorinostat(SAHA),romidepsin(F
目的 合成一系列作用于DNA小沟的DB766末端取代衍生物8a-8o,测定其体外抗四种寄生虫活性。方法 以2-氨基-5-硝基苯酚为起始原料,经溴代、异丙基化、与2,5-二(三正丁基锡)呋喃发生Stille偶联反应、氢气还原等制备关键中间体2,5-二[4-氨基-2-(2-异丙氧基)苯基]呋喃,该中间体与各种S-(2-萘甲基)-2-硫代亚氨基乙酸酯氢溴酸盐得到目标化合物。
The thiazolidinedione class PPARγ agonists as antidiabetic agents are restricted in clinical use because of the side effects such as edema,weight gain and heart failure.The single and selective agonis