【摘 要】
：
Objective: To evaluate the permeability and safety of a drug delivery system for the inner ear using a poly(2-hydroxyethyl aspartamide) (PHEA) polymersome.Methodology: One-month-old male C57/BL6 mice
【机 构】
：
The Catholic University, Daejeon, Korea KAIST, Da
【出 处】
：
The 4th East Asian Symposium on Otology(第四届东亚耳科研讨会)
论文部分内容阅读
Objective: To evaluate the permeability and safety of a drug delivery system for the inner ear using a poly(2-hydroxyethyl aspartamide) (PHEA) polymersome.Methodology: One-month-old male C57/BL6 mice were used.We administered the same amount of the fluorescent dye,Nile red, into the middle ear in two forms: loaded in PHEA polymersomes (NP group) or diluted in ethanol (NR group).At 1 day after administration, we harvested the cochlea and counted visible red particles in the tissues of cochlea under confocal microscopy and compared the groups.In a safety evaluation, 1 week after the same surgery, we conducted hearing tests and histological evaluations of the bulla and cochlea, and compared the results with those of the sham operation and negative control groups.
其他文献
Objective: To explore the incidence ofEndolymphatic hydrops by 3D-FLAIR MRI in the contralateral ear in patients with unilateral Ménières disease.Methodology: This was a prospective study.3D-FLAIR MRI
Objective: To describe two cases of facial nerve paralysis resulted from intracranial portion injury secondary to blunt trauma without a temporal bone fracture.Methodology: Clinical case report and li
Objective: To investigate the evaluation of external auditory canal irrigators in clinical application.Methodology: A total of 115 patients including 144 ears with suppurative otitis media were enroll
Objective: To investigate the expression of EFR3A protein in the cochlea during the degeneration of the spiral ganglion neurons (SGNs) following sensorineural hearing loss in mice.Methodology: C57BL/6
Objective: Noise-induced hearing loss has been associated with alterations in cochlear blood flow.This study analyzed the expression of vascular endothelial Methodology: Acoustic trauma was induced by
Objective: To analyze the reasons of the poor rehabilitative effect in 7 cases after cochlear implant surgery.Methodology: A retrospective case review was conducted on 7 cochlear implant cases who acc
Objective: To describe the characteristics, diagnosis, management and outcomes of facial nerve schwannomas (FNSs).Methodology: Patients whose outpatient diagnosis was facial nerve tumor and whose intr
Objective: The aim of present study was to investigate images of 3D-T1 fast spin echo sequence in the endolymphatic space in patients with Menieres disease and low frequency sensorineural hearing loss
Objective: To analyze retrospectively the functional outcome of the facial nerve after different nerve rerouting techniques in the procedure of removal of jugular foramen tumors, and to discuss their
Objective: To evaluate the development of hearing in a child with cochlear nerve deficiency (CND).Methodology: Cochlear nerve deficiency (CND) is believed to be associated with profound hearing loss a