Ischemic stroke is a dominant health problem with extremely high rates of mortality and disability.The mainmechanism of neuronal injury after strokeis excitotoxicity during which the activation of neuronal nitric oxide synthase(nNOS)exerts a vital role.However,directly blocking N-methyl-D-aspartate receptors(NMDARs)or nNOS can lead to severe undesirable effects since they have crucial physiological functions in central nervous system(CNS).