【摘 要】
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Apoptosis of osteoblasts induced by glucocorticoid (GC) has been identified as a major cause of osteoporosis,bone loss and fractures,and the oxidative stress was found as an important contributor.Ther
【出 处】
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中华医学会第八次全国骨质疏松和骨矿盐疾病学术会议
论文部分内容阅读
Apoptosis of osteoblasts induced by glucocorticoid (GC) has been identified as a major cause of osteoporosis,bone loss and fractures,and the oxidative stress was found as an important contributor.Therefore,natural or synthetic agents with antioxidant activities can antagonize GCs-induced apoptosis in osteoblasts,and thus demonstrate application potential to reverse osteoporosis.In this study,we showed the,indole-3-carbinol (13C),a natural product found in broadly consumed plants of the Brassica genus,could block the cytotoxic effects of dexarnethasone (Dex),and elucidated the underlying molecular mechanisms.Firstly,we showed that,I3Ccould effectively suppress Dex-induced cytotoxicity and apoptotic cell death in osteoblastic cells,as evidenced by the decrease in Sub-G1 cell population.
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