论文目的：L-35 is a novel heterodimeric and inhibitory cytokine that belongs to the IL-12 family and is composed of interleukin-12 subunit alpha (P35) and Epstein-Barr virus-induced gene 3 (EBI3).论文方法：IL-35 has been reported to be produced by a range of cell types, especially regulatory T cells,and to exert immunosuppressive effects via the STATx signaling pathway.In this study, we demonstrated that IL-35 expression was elevated in both serum samples and tumors in patients with colorectal cancer.