【摘 要】
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Background & Aims The woodchuck model is an informative model for studies on hepadnaviral infection.In this study, woodchuck hepatitis virus (WHV) transgenic (Tg) mouse models based on C57BL/6 mice we
【机 构】
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Department of Infectious Diseases, Taihe Hospital, Hubei University of Medicine, Shiyan, China;Insti
【出 处】
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中华医学会第十六次全国病毒性肝炎及肝病学术会议
论文部分内容阅读
Background & Aims The woodchuck model is an informative model for studies on hepadnaviral infection.In this study, woodchuck hepatitis virus (WHV) transgenic (Tg) mouse models based on C57BL/6 mice were established to study the pathogenesis associated with hepadnaviral infection.Methods C57BL/6 mice were used to establish WHV Tg mice.WHV replication intermediates were detected by Southem blotting.DNA vaccines against WHV proteins were applied by intramuscular injection.WHV-specific immune responses were analyzed by flow cytometry and ELISA.
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