miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSM

来源 :2014年第十二届全国脂质与脂蛋白学术会议 | 被引量 : 0次 | 上传用户：ktv238

【摘要】

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The regulation of vascular smooth muscle cell (VSMC) proliferation is an important issue due to its major implications for the prevention of pathological vascul

【作者】

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Bin Zheng Xin-hua Zhang Chan-quan Nie Yong hui Li Yong Zhang Hui-jing Shi Yan Liu Cui-ying Zheng Tian Zhang Jin-kun Wen

【机构】

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DepartmentofBiochemistryandMolecularBiology,HebeiMedicalUniversityDepartmentofUrinarySurgery,SecondH

【出处】

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2014年第十二届全国脂质与脂蛋白学术会议

【发表日期】

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2014年10期

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The regulation of vascular smooth muscle cell (VSMC) proliferation is an important issue due to its major implications for the prevention of pathological vascular conditions.We found that miR-200c inhibited the expression of Krüppel-like transcription factor 4 (KLF4) and the SUMO-conjugating enzyme Ubc9 under basal conditions.Binding of unSUMOylated KLF4 with p300 activated p21 (p21wAF1/cw1) transcription leading to VSMC growth arrest.

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miR-200c-SUMOylated KLF4 feedback loop acts as a switch in transcriptional programs that control VSM

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