【摘 要】
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Objective To investigate the protective effect of biliary tract external drainage(BTED) on rats with severe acute pancreatitis(SAP) and its mechanism.Methods Adult male SD rats weighing 250-300g were
【机 构】
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Department of Emergency ICU,Ruijin Hospital,Shanghai Jiaotong University School of Medicine
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Objective To investigate the protective effect of biliary tract external drainage(BTED) on rats with severe acute pancreatitis(SAP) and its mechanism.Methods Adult male SD rats weighing 250-300g were randomly divided into three groups: sham surgery group (SS), SAP group and SAP+BTED group.SAP was induced by injecting 4％ sodium taurocholate 1 mL/kg retrograde pancreatic duct.BTED was performed by inserting a cannula into the bile duct for bile save.The tissues and blood samples were harvested 24 hours after operation for biochemical and cytokine measurements.The pathological changes of pancreas, liver, lung and intestine were observed and scored.The serum levels of amylase and ALT, AST, diamineoxidase (DAO), and lipopolysaccharide (LPS) were measured.The contents of myeloperoxidase (MPO) in lung were detected by enzyme-linked immunosorbent assay (ELISA).The messenger RNA expression of heme oxygenase-1(HO-1) and tumor necrosis factor-α (TNF-α)□in organs were tested by realtime-PCR.
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