To analyze the clinicopathological characteristics and change pattern of prostate cancer (PCa) in the Institute of Urology, Peking University (IUPU) during the last 15 years.We reviewed the data of patients with biopsy confirmed and surgery confirmed PCa in IUPU during the last 15 years, which were chronologically divided into 2 groups, 2001-2010 and 2011-2015, respectively.The clinicopathological data between groups were compared.We identified 2313 patients with biopsy confirmed PCa and 1030 patients with surgery confirmed PCa.For the patients with biopsy and surgery confirmed PCa, the mean age were 70.67 ± 0.18 and 65.78 ± 0.28,respectively.We found a significant difference in the Gleason score between the patients with biopsy and surgery confirmed PCa (7.75 ± 0.03 vs.7.32 ± 0.03, P＜0.001).The median number of cores was 12 (range 3-19) with only 28.9％ ≤ 11.For the biopsy patients, there were significant difference in both core number (P＜0.001) and Gleason score (P＜0.001) between the group 2001-2010 (n=1094, 11.23 ± 0.10, 7.89 ± 0.04) and 2011-2015 (n=1218,11.81 ± 0.09, 7.62 ± 0.03).For the patients with surgery confirmed PCa, there was no difference in Gleason score (P=0.085) or age (P=0.699) between the group 2001-2010 (n=412) and 2011-2015 (n=618).There was a trend of T3 increase that the percentage of T3 was 47.4％ and 52.6％ in group 2001-2010 and 2011-2015, respectively.However, the difference was not significant (P=0.110).