生物活性肽协同化疗药物对人胃癌干细胞增殖的影响

来源 :中国细胞生物学学会2015年全国学术大会 | 被引量 : 0次 | 上传用户:gaoyijie1983
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  背景和目的:胃癌的发生及死亡率长期居全球癌症的前列。新近的研究证实,肿瘤干细胞不仅是肿瘤发生的核心,而且具有极强的抵抗细胞毒药物、抗放射治疗的特点,且与肿瘤的复发、肿瘤内的新生血管形成以及肿瘤的转移关系密切。前期的研究中,我们证实了拥有自主知识产权的生物活性肽(ACBP)与化疗药物结合可以提高抗癌效果并且提高荷瘤裸鼠生活质量的作用。本文从细胞及动物体内实验深入证实了ACBP协同化疗药物对胃癌干细胞的作用及机制。
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