We have investigated new designs for mechanochemically-reactive species(mechanophores)and the ability to amplify mechanochemical responses via triggered depolymerization.Our new mechanophore designs are capable of activation via force-guided bond bending motions,as opposed to more common approaches that utilized bond elongation.Key features of our design include the ability to release an organic small molecule as the chemical output arising from mechanical input,and mechanochemical reactivity that does not inherently require bond scission within the polymer main chain.In addition to our recent results on these “flex activated” mechanophores,new strategies for polymer synthesis will be discussed.