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Purpose To investigate the mechanisms of adriamycin(ADR)for proliferative vitreoretinopathy(PVR)treatment by using human retinal pigment epithelial(RPE)-derived(ARPE-19)cells.Methods Cultured ARPE-19 cells were treated with 1 to 2μM ADR,and the cell viability was quantified using sulforhodamine B(SRB)assay.