论文部分内容阅读
Human diseases associated with selective autophagy pathways
【机 构】
:
Division of Biological Sciences, Section of Molecular Biology, University of California San Diego, L
【出 处】
:
The 7th International Symposium on Autophagy 2015(第七届自噬国际研讨会
【发表日期】
:
2015年期
其他文献
Mutations in the PINK1 and PARK2 genes are associated with Parkinson's disease, and the corresponding proteins Pink1 and Parkin are critical in the removal
会议
Many neurodegenerative diseases are characterized by abnormal accumulations of insoluble protein aggregates, such as Amyloid beta oligomers in Alzheimer's d
会议
Stress-Responsive MAPK Family Members, MK2/MK3, Activate Starvation-Induced Autophagy through Beclin
Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by a set of evolutionarily conserved gene products, the autophagy (ATG) p
会议
(Macro-)Autophagy describes a process responsible for the degradation of intracellular proteins and organelles.In recent years, the ULK1/2 complex comprisin
会议
Activating mutations in the RAS oncogene are common in cancer but are difficult to therapeutically target.RAS activation promotes autophagy, a highly regula
会议
During starvation, autophagy degrades cytoplasmic constituents including organelles such as ER and mitochondria.It remains unclear to what extent and how or
The presence of multiple homologs of the same Atg gene in multicellular organisms confers a layer of complexity on the more elaborate autophagic machinery.Howev
会议
Overexpression Atg1 rescues pink1/parkin muscle degeneration by promoting mitochondrial fission Dros
Mitochondria dysfunction is considered as a hallmark of multiple neurodegenerative diseases,such as Parkinson's disease (PD).Mutations in two PD related gen
会议
The autophagy-linked FYVE protein (ALFY) is a large multi-domain protein implicated in the selective degradation of ubiquitinated protein aggregates by autophag
会议
Stem cells are critical for the maintenance of adult tissues and organs, including the intestinal tract of mammals and Drosophila.We find that intestinal stem c
会议