MiR-208通过下调P21介导胰岛素刺激血管平滑肌细胞异常增殖的实验研究

来源 :第二届中国高血压大会暨中国医师协会高血压专业委员会年会 | 被引量 : 0次 | 上传用户：betterman_swp

【摘要】

：

目的血管平滑肌细胞(VSMC)异常增殖是高血压发生发展的重要病理生理机制之一,高浓度胰岛素促进VSMC 增殖,诱发或加重高血压的血管病变.鉴于胰岛素复杂的生理效应,胰岛素引起VSMC 的异常增殖仍有许多不清楚之处,我们推测可能存在其他的关键分子及机制.寻找高胰岛素血症引起VSMC 增殖的确切机理对于防治动脉粥样硬化具有重要意义.

【作者】

：

张晔王燕王旭开曾春雨

【机构】

：

第三军医大学大坪医院心血管病专科医院心内科、重庆心血管病研究所第三军医大学分子遗传教研室

【出处】

：

第二届中国高血压大会暨中国医师协会高血压专业委员会年会

【发表日期】

：

2012年9期

【关键词】

：

胰岛素血管平滑肌细胞 miR-208 p21

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Is serum ferritin<15μg/l appropriate for identifying iron deficiency among marginal anemia popula

会议

WHO CriterionIron DeficiencyMarginal Anemia

The effect of inflammation and iron overload on the expression of iron-sulfur protein and thio-modif

会议

InflammationtRNA Thio-modificationIron-sulfur Protein

A Randomized Controlled Trial Investigating the Effect of Calcium Supplementation on Iron Status in

会议

IronAnemiaCalciumSupplementation

Non-heme iron does not interact with heme iron absorption in humans

会议

Heme IronNon-heme IronAbsorption

Speciation and bioavailability of selenium in soil from Enshi,China

会议

SeleniumSoilBioavailability

Study on the Correlation between Selenium Levels and APOE Gene Polymorphism in Aged People in Rural

会议

SeleniumGene polymorphismAged people in rural

Identification and verification of transcriptional networks involved in iron homeostasis and oxidati

会议

Transcriptional NetworksCopperIronOxidative Stress Damage

Determination of selenium in food by atomic fluorescence spectrometry

会议

Atomic fluorescence spectrometryfood and waterselenium

Hypertension is a risk factor for developing left ventricular systolic dyssynchrony in Patients with

Background Myocardial bridge (MB) is a common finding during selective coronary angiography.So far,the clinical significance of MB is controversial.In general,MB is regarded as a benign process.Howeve

会议

myocardial bridgecoronary angiographyleft ventricular systolic dyssynchronyre

Impaired endothelial progenitor cell activity is associated with reduced arterial elasticity in pati

Objective Endothelial dysfunction is related to reduced arterial elasticity in patients with essential hypertension.Circulating endothelial progenitor cells (EPCs),an important endogenous repair appro

会议

HypertensionEndothelial progenitor cellsArterial elasticityEndothelial functi

MiR-208通过下调P21介导胰岛素刺激血管平滑肌细胞异常增殖的实验研究

与本文相关的学术论文