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  5. Epigenetic silencing of PGLYRP2 attenuates host immune responses against hepatocellular carcinoma

Epigenetic silencing of PGLYRP2 attenuates host immune responses against hepatocellular carcinoma

来源 :中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议 | 被引量 : 0次 | 上传用户：yuantxunda
【摘 要】
：
Hepatocellular carcinoma(HCC)is linked to inflammation and immunosuppression.PGLYRP2 is an innate immune pattern recognition receptor(PRR),which is specifically expressed in liver tissue and implicate
【作 者】
：
Shuai Zhang Yu Tang Zhengxiong Ma Ming Shi 
【机 构】
：
School of Life Science and Technology,Harbin Institute of Technology,Harbin,China
【出 处】
：
中国生物化学与分子生物学会第十二届会员代表大会暨2018年全国学术会议
【发表日期】
：
2018年10期
【关键词】
：
PGLYRP2 Hepatoma Immune responses 
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　　Hepatocellular carcinoma(HCC)is linked to inflammation and immunosuppression.PGLYRP2 is an innate immune pattern recognition receptor(PRR),which is specifically expressed in liver tissue and implicated in the regulation of inflammation.However,the role of PGLYRP2 in HCC remains unclear.In this study,we aimed to investigate the epigenetic mechanism of PGLYRP2 silencing in HCC tissues and whether PGLYRP2 is able to influence HCC progression by regulating tumorassociated inflammation.
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