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  5. Metabolism and distribution of newly anti-inflammatory HMGB1 A Box fused with C-terminal acidic tail

Metabolism and distribution of newly anti-inflammatory HMGB1 A Box fused with C-terminal acidic tail

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：liusiyu111
【摘 要】
：
Recombinant derived proteins are becoming increasingly important as therapeutic agents.HMGB1, composed of the A box, B box and C tail domains, is a critical proinflammatory cytokineinvolved in diverse
【作 者】
：
wei gong Shibin Feng Ting Yang Yan Zhang Fengtian He 
【机 构】
：
Department of Biochemistry and Molecular Biology,College of Basic Medical Sciences,Third Military Me
【出 处】
：
中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议
【发表日期】
：
2014年3期
【关键词】
：
HMGB1 Fusion protein Inflammation 125I-radiolabeled Metabolism and distribution 
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Recombinant derived proteins are becoming increasingly important as therapeutic agents.HMGB1, composed of the A box, B box and C tail domains, is a critical proinflammatory cytokineinvolved in diverse inflammatory diseases.The B box mediates proinflammatoryactivity, while the A box alone acts as a specific antagonist of HMGB 1.
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