Uracil-DNA glycosylase UNG promotes Tet-mediated DNA demethylation

来源 :第十一次全国基因功能与表观遗传调控学术研讨会 | 被引量 : 0次 | 上传用户：qaz1164

【摘要】

：

In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases

【作者】

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薛剑煌徐国良

【机构】

：

中科院上海生科院生化细胞所分子生物学国家重点实验室,上海市岳阳路320号,200031,中国

【出处】

：

第十一次全国基因功能与表观遗传调控学术研讨会

【发表日期】

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2015年10期

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In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases and excision of these two oxidized bases by thymine DNA glycosylase (TDG).

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Uracil-DNA glycosylase UNG promotes Tet-mediated DNA demethylation

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