【摘 要】
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Purpose: The Wnt genes are involved in embryogenesis and tumorigenesis.Among them, Wnt1 stimulates the canonical Wnt/beta-catenin signaling pathway, which regulates the transcription of many Wnt-targe
【机 构】
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Department of General Thoracic Surgery Breast and Endocirnological Surgery Kagawa University Japan
【出 处】
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BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
Purpose: The Wnt genes are involved in embryogenesis and tumorigenesis.Among them, Wnt1 stimulates the canonical Wnt/beta-catenin signaling pathway, which regulates the transcription of many Wnt-target genes with TCF/LEF1 motif.The Wnt-target genes include various molecules associated with tumorigenesis.We have reported that Wnt 1 over expression promotes tumorigenesis in non-small cell lung cancer (NSCLC) through the induction of c-Myc, cyclin D1, vascular endothelial growth factor-A (VEGF-A) (Huang C, et al.Eur J Cancer 2008).Recently, survivin, a member of the inhibitor of apoptosis protein (IAP) family, is reported to be a target gene of the canonical Wnt signaling pathway.In addition, we have found the survivin gene expression affect tumor biology in NSCLC (Nakano J, et al.Br J Cancer 2008).
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