This study aims to investigate the underlying mechanism by which curcumin (Cur) inhibits tumor growth and reduces vasculogenic mimicry (VM) in a murine choroidal melanoma model.Sixty mice were given subretinal injection with B16F10 cells and divided into a treatment and a control group.Curcumin is administered to the treatment group once a day at a dose of 100 mg/kg for 18 days starting at d3 (the day of inoculation is designated as d0); an equivalent volume of poloxamer-F68 is administered to the control group.Double immunostaining is performed to detect the different blood supply patterns.