Chamber plays a important role in the detecting process of electronic nose.A new bionic chamber for electronic nose was designed by studying flow field and geometry features in mammal nose such as human nose.We optimized the bionic chamber based on orthogonal experiment,and found both detection sensitivity and accuracy of the electronic nose with bionic chamber had a great improvement compared with those without bionic chamber.The fluid dynamic analysis of bionic chamber was carried out by creating a 3D model of the chamber,showed distributions of flow field in the chamber were similar to those in mammal nose.Thus,this made detected gas not only mixing more uniform in the chamber but can contact for a longer time with sensors.The bionic chamber can improve performance of electronic nose exactly.