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5. Smurf1 functions as a thioester bond intermediate-type Nedd8 ligase to promote colorectal cancer

Smurf1 functions as a thioester bond intermediate-type Nedd8 ligase to promote colorectal cancer

来源 :中国细胞生物学学会2013年全国学术大会 | 被引量 : 0次 | 上传用户：q3177848

【摘 要】

：

Neddylation is essential for the viability of most model organisms and involved in cancer development.In contrast with more than 600 ubiquitin ligases are known,less than ten Nedd8 ligases have been i

【作 者】

：

Ping Xie Minghua Zhang Shan He Guichun Xing Yu Cui Yu Cao Yawen Tan Nan Chai Jiawei Wu Haiteng Deng Jing Nie Fuchu He Ling qiang Zhang 

【机 构】

：

State Key Laboratory of Proteomics,Beijing Proteome Research Center,Beijing Institute of Radiation M

【出 处】

：

中国细胞生物学学会2013年全国学术大会

【发表日期】

：

2013年12期

【关键词】

：

neddylation E3 ligase Nedd8 ubiquitin Smurf1 colorectal cancer 

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Neddylation is essential for the viability of most model organisms and involved in cancer development.In contrast with more than 600 ubiquitin ligases are known,less than ten Nedd8 ligases have been identified.

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