Pyrimidines have been recognized as important heterocyclic compounds due to their diverse biological activities such as HIV-1 inhibitor,antimalarial,antibacterial,anticancer,analgesic,cardiovascular,and antiallergic activities.Meanwhile,Benzimidazole moiety is a structural isostere of naturally occurring nucleotides and it has been extensively utilized as a drug scaffold in the medicinal chemistry.In this paper,a series of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidines were designed and synthesized(Scheme1).