Objective Chronic hepatitis B virus (HBV) infection is the most common cause of hepatic fibrosis and hepatocellular carcinoma (HCC).Chronic hepatitis B (CHB) appears to progress more rapidly in males than in females and hepatic cirrhosis as well as HCC are predominately diseases that tend to occur in men and postmenopausal women.However the mechanisms that account of this gender disparity remain unclear.Our objective here is to systematically identify relevant biomarkers and to pinpoint pathways that are differently affected by transgene HBV in male and female mice.