Introduction: Pulmonary hypertension induced by monocrotaline(MCT)is mainly through exposure of collagen fibers,pulmonary artery thrombosis,and a series of pathological changes,such as smooth muscle cell proliferation.Potassium channels are widely existed in pulmonary artery smooth muscle cells(PASMCs),which participate in the regulation of proliferation and apoptosis,and have important influence on pulmonary vascular remodeling.