【摘 要】
：
初步研究镇脑宁胶囊对偏头痛的镇痛作用及脑内单胺类神经递质的影响。采用利血平负荷血凝块注射建立实验性偏头痛小鼠模型。热板法观察镇脑宁胶囊对偏头痛模型动物痛阈的影响；荧光分光光度法测定小鼠脑内单胺类神经递质去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)含量。利血平负荷血凝块可使小鼠痛阈降低，单胺类神经递质显著降低，成功诱导实验性偏头痛小鼠模型。镇脑宁胶囊2
【机 构】
：
北京中医药大学中药学院,中药基础与新药研究北京市重点实验室,北京 100102 通化东宝药业股份有
【出 处】
：
全国中药药理学会联合会学术交流大会
论文部分内容阅读
初步研究镇脑宁胶囊对偏头痛的镇痛作用及脑内单胺类神经递质的影响。采用利血平负荷血凝块注射建立实验性偏头痛小鼠模型。热板法观察镇脑宁胶囊对偏头痛模型动物痛阈的影响；荧光分光光度法测定小鼠脑内单胺类神经递质去甲肾上腺素(NE)、多巴胺(DA)、5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)含量。利血平负荷血凝块可使小鼠痛阈降低，单胺类神经递质显著降低，成功诱导实验性偏头痛小鼠模型。镇脑宁胶囊200～800 mg/kg可不同程度改善模型动物偏头痛症状，其中800 mg/kg剂量可显著提高痛阈值27％，分别提高脑内NE、DA、5-HT和5-HIAA含量达34％、33％、20％和30％。镇脑宁胶囊可以治疗利血平化伴局部脑血管痉挛所致小鼠偏头痛。
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