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Background: It was unknown that the serum matrix metalloproteinase-2 (MMP2) and bone sialoprotein (BSP) levels would be the key to osteoporosis.We would to study the serum matrix metalloproteinase-2 (MMP2) and bone sialoprotein (BSP) levels and the correlations of MMP2 and BSP with bone metabolic markers and bone mineral density (BMD) in aged postmenopausal Chinese women.