由于过去长期使用有机氯,有机磷等类化学杀虫剂灭蚊,不仅产生抗药性使得药效下降,同时也污染环境。 1966年联合国卫生组织,开始在世界各地寻找分离蚊虫的病原菌,拟进行生物防治,1976,1977Ramasha与Goedbery等先后分离到对蚊虫有高度敏感的球形芽孢杆菌(B.sphaeriens)与苏云金杆菌以色列变 Due to the long-term use of organochlorine and organophosphate pesticides such as organophosphates, mosquitoes not only produce drug resistance, but also reduce the efficacy and pollute the environment. In 1966, the United Nations World Health Organization began to search for pathogenic bacteria isolated from mosquitoes all over the world and proposed biological control. In 1976, 1977, Ramasha and Goedbery successively isolated B.sphaeriens and B. thuringiensis isolates which were highly susceptible to mosquitoes.