【摘 要】
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Background, Motivation and Objective A non-scanning 2D shear wave (SW) imaging method based on laser speckle contrast imaging (LSCI) was previously developed, where a SW velocity estimation error of l
【机 构】
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Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan
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Background, Motivation and Objective A non-scanning 2D shear wave (SW) imaging method based on laser speckle contrast imaging (LSCI) was previously developed, where a SW velocity estimation error of less than 4％ was achieved on homogeneous phantoms. In this report, the method is extended with a wide field microscope that both 3D structural and SW imaging can be performed. We hypothesize that 3D SW imaging based on optical-sectioned LSCI can achieve sub-millimeter resolution for samples with thickness less than 3mm. This method is suitable for applications in 3D cell culture analysis. The composition and biomechanical properties of the extracellular matrix contribute to the structural support and the regulatory functions of the cell microenvironment. Studies have shown that ECM stiffening may promote cancer cell invasion and migration. Thus, in vitro analysis of the topology and the stiffness of the 3D matrix can provide information about the dynamics of the cell and its microenvironment during tissue development and pathogenesis.
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