Inhibition of 6-phosphogluconate dehydrogenase reverses cisplatin resistance in ovarian and lung can

来源 :2016医学科学前沿暨第四届个体化治疗与抗肿瘤药物研究新趋向研讨会 | 被引量 : 0次 | 上传用户:cmcbst
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Cisplatin is currently one of the most effective chemotherapeutic drugs for the treatment of ovarian and lung cancer.Whereas,resistance to cisplatin is common and it often leads to local and distant failure.
其他文献
Pancreatic cancer(PC)is one of the most aggressive human malignancies worldwide and is the fourth leading cause of cancer-related deaths.Curcumin(diferuloylmethane)is a polyphenol derived from the Cur
会议
2011 年开始,恶性肿瘤已经超过心脏病,已经成为全球第一大死亡原因.进入21世纪以来一直以来,以免疫学为基础建立起的肿瘤免疫疗法已成为继手术、化疗、放疗和靶向治疗后的一种新的有效疗法.针对免疫检查点的阻断是众多激活抗肿瘤免疫的有效策略之一.PD-L1,作为T 细胞表面PD-1 的配体高表达于多种恶性肿瘤细胞的表面,其与PD-1相互作用后可以抑制T 细胞的增殖,细胞因子的释放从而抑制机体对于肿瘤细
会议
Tumor drug resistance is the main reason for the failure of tumor chemotherapy,but the underlying mechanisms are various,which is a big problem in the clinical treatment.A large number of studies have
会议
Chronic myeloid leukemia(CML)is a clonal malignant disorder of pluripotent hematopoietic stem cells(HSCs)characterized by the formation of the novel breakpoint cluster region-Abelson tyrosine kinase(B
会议
Triple-negative breast cancer(TNBC)are characterized by high vascularity and frequent metastasis.Here,we found that activation of G protein-coupled estrogen receptor(GPER)by its specific agonist G-1 c
会议
会议
会议
Background: Bisphenol A(BPA)is a chemical with widespread human exposure suspected of causing low-dose effects.Bisphenol-S(BPS)which structurally similar to BPA is intended to replace BPA in plastic.
会议
会议