【摘 要】
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Background,Motivation and Objective Bisphosphonates(BP) like zoledronic acid(ZOL) have demonstrated clinical utility in the treatment of patients with bone metastases.However,ZOL exhibits antitumor ef
【机 构】
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INSERM UMR 1032,Lyon,France INSERM UMR 1032,Franc
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Background,Motivation and Objective Bisphosphonates(BP) like zoledronic acid(ZOL) have demonstrated clinical utility in the treatment of patients with bone metastases.However,ZOL exhibits antitumor effects only at high doses incompatible with a clinical use due to renal toxicity.Bisphosphonates exhibit a high affinity for bone mineral,which reduces their bioavailability for tumor cells.We examined if low intensity ultrasound could enhance the effects of a clinically relevant dose of ZOL in experimental breast cancer and bone metastasis murine models.
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