• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. A potential injectable and biodegradable thermo-sensitive hydrogel system loaded with PLGA nanoparti

A potential injectable and biodegradable thermo-sensitive hydrogel system loaded with PLGA nanoparti

来源 :2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会 | 被引量 : 0次 | 上传用户：dickensking
【摘 要】
：
Biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) containing interferon (IFN) α-2b were loaded in chitosan-based thermosensitive hydrogels for sustained delivery of IFN.The inject
【作 者】
：
CHEN Gang DAI Juan WEN Lu 
【机 构】
：
School of Pharmacy, Guangdong Pharmaceutical University, Guangzhou 510006, China
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
【发表日期】
：
2015年9期
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
　　Biodegradable poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) containing interferon (IFN) α-2b were loaded in chitosan-based thermosensitive hydrogels for sustained delivery of IFN.The injectable hydrogels, formed by slowly adding β-glycerophosphate sodium (GP) solution to chitosan (CS) solution under constant stirring, displayed a rapid sol-to-gel transition at 37℃, a porous structure and fine degradation characteristic and swelling rate in vitro.
其他文献
Nanomedicine strategies for sustained, controlled and targeted treatment of cancer stem cells
Cancer stem cells (CSCs) are original cancer cells that are of characteristics associated with normal stem cells.CSCs are toughest against various treatments and thus responsible for cancer metastasis
会议
Tumor repopulation was blocked by doxorubicin-loaded glycolipid-structured micelles with reduced can
Repopulation of surviving tumor cells is an important cause of treatment failure.Cancer stem cells (CSCs) are the root of cancer and responsible for caner relapse and drug resistance.They could surviv
会议
Surface sperimidine functionalized, fluorofenidone-loaded PEG-PLGA nanoparticles for enhanced treatm
Despite significant efforts have been made to prevent paraquat (PQ)-induced pulmonary fibrosis,including corticosteroids and immunomodulatory agents, sufficient therapeutic method has remained underde
会议
FluorofenidoneSpermidinePolyamine transport systemParaquatPulmonary fibrosis
Tumor microenvironment responsive system with two-step drug release for combinatory and synergistic
The complicated pathogenesis plays a key role in the sustained growth of solid tumor.Conventional single therapeutic agents show low selectivity towards a specific target, and display serious side eff
会议
tumor microenvironmentcombination therapysynergistic effectantiangiogenesisH
Yeast cell wall particles thickened with thermosensitive gels as potential carriers for oral deliver
The oral route presents a major barrier to macromolecular drugs, whose oral bioavailability is invariably well below the therapeutic level.Especially for proteins and peptides because of their gastric
会议
yeast cell wall particleinterior gelationinsulin carrieroral deliveryabsorpt
A novel Soluplus(R)-dispersed sustained-release tablet for imperialine to simultaneously prolong the
Imperialine, extracted from Bulbus Fritillariae Cirrhosae, is an efficient antitussive and expectorant medicine.However, its short half-life and stomach degradation limited imperialine from further cl
会议
ImperialineSustained-release tabletSoluplus(R)in vitro dissolutionBeagle dog
Construction of CPP-based Fusion Trichosanthin with MMP-2 Responsive PEGylation Using Intein-mediate
Tricosanthin (TCS), a type Ⅰ ribosome-inactivating protein that has been used for midterm abortion in traditional Chinese medicine, can depurinate rRNA and inhibit protein synthesis, thus efficiently
会议
tricosanthinIntein-mediated protein ligationCPPMMP-2PEGtumor-targeting deli
Cellular uptake mechanism, intracellular fate and exocytosis of polyamidoamine dendrimers in MCF-7 c
PAMAM dendrimers have been attracting more attention for delivering drugs and genetic materials to resistant cells.However, the intracellular transport behavior of PAMAM dendrimers in resistant cells
会议
PAMAM dendrimersMultidrug resistanceEndocytosisIntracellular transportationE
Novel multifunctional “nano-eggs” for drug delivery to cancer cells and cancer stem cells based on p
In this study, we prepared a multifunctional oligosaccharides of hyaluronan (oHA) conjugates,oHA-histidine-menthone 1,2-glycerol ketal (oHM).The oHM conjugates possess pH-sensitive menthone 1,2-glycer
会议
Dually pH/Reduction-Responsive Vesicles for Ultrahigh-Contrast Fluorescence Imaging and Thermo-Chemo
Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics.Herein, as a proof-of-concept, we report dually pH/reduction-responsi
会议
vesiclesstimuli-responsive releasecancer imagingphotothermal therapysynergis