【摘 要】
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Background: Ultra-minimum incision personalized intratumoral chemoimmunotherapy (UMIPIC) is a new option for cancer treatment integrating local chemotherapeutic effect with systematic antitumor immuni
【机 构】
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Jinan Baofa Cancer hospital, Jinan, 250117, China;TaiMei Baofa Cancer hospital, Dongping, 271500, Ch
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Background: Ultra-minimum incision personalized intratumoral chemoimmunotherapy (UMIPIC) is a new option for cancer treatment integrating local chemotherapeutic effect with systematic antitumor immunity by intratumoral drug delivery, which is comprised of three components, an oxidant, a cytotoxic drug (cytosine arabinoside;Ara-C) and a hapten.Having injected the composed agents, the autologous tumor-associated antigens released from dead tumor cells killed by coagulation (or Ara-C) then trigger immune response as self-vaccination.Meanwhile, a small hapten molecule binds to these antigens and other large carriers boost the systemic hormonal and cellular immunity, leading to suppression and eradication of the tumor including its metastatic foci.
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