Recent studies have identified a number of HIV restriction factors.Thus,we examined the expression of several key antiviral cellular factors(OAS-1,MxA,A3G,PKR and Tetherin)in PBMCs from HIV-infected patients before and during the course of antiretroviral therapy.Compared with uninfected control subjects,age-matched HIV-infected individuals have lower levels of the antiviral factors in PBMCs prior to the antiretroviral therapy.