Objectives: To explorethe effect of alphaasarone on neuronal apoptosis, apoptosis rate with mitochondrial damage, and changesin neuron cellular ultrastructure in Sombati s model of epilepsy.Methods :D
目的：构建大鼠整合素β1基因(integrinβ 1) RNA干扰慢病毒载体,为研究Sombati癫痫细胞模型integrin β 1的作用机制提供载体。方法 构建integrin β 1基因的4个shRNA慢病毒干扰载体,利用HEK 293T细胞进行慢病毒包装,感染靶细胞PC12,采用WestemBlot验证干扰效果,筛选出沉默效果最好的慢病毒shRNA,感染新生大鼠海马神经元细胞和Sombat
Purpose: The sodium channel α 1 subunit (SCN1A) gene is associated with febrile seizures (FS)-related epilepsies.The mutation types ofSCN 1 A, such as truncation, sphcesite and missense mutations, are
Background: Despite several studies investigating the association between human leukocyte antigen HLA-B* 1502 and lamotrigine-induced Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN
Purpose: Tocharacterizetheclinicaland genetic features of febrile seizures related epilepsy in Chinese patients.Methods :Total 940 patients were divided into 5 groups,which included repetitive febrile
目的：惊厥性癫痫持续状态(convulsive status epilepticus,CSE)是神经内科常见急症,探讨影响CSE急诊治疗效果的相关因素的分布规律,完善对癫痫急诊的认识,为临床诊治提供理论依据,以及为制定CSE的预防以及控制对策提供科学依据。
目的：观察结节性硬化患者的视频脑电图(VEEG)、CT变化及其与临床的关系。方法 对5例结节性硬化患者分别进行EEG、CT检查，并对检查结果进行分析。结果 VEEG异常5例，表现为痫样放电4例；5例cT均有异常，表现为侧脑室室管膜下或侧脑室体外侧壁散在性类圆形结节状钙化灶，不同程度向侧脑室内突出。结论 结节性硬化患者EEG异常率较高，痫样放电多见，能客观反映患者的脑功能状况，对癫痫的早期诊断、癫痫
Purpose: Stevens-Johnsonsyndrome(SJS) and toxic epidermal necrolysis (TEN) are rare but severe cutaneous adverse reactions (SCAR) caused by a certain number of medications including antiepileptic carb
目的:颞叶癫痫患者的颞叶白质联络纤维损伤常见,如钩束、穹窿、扣带束、弓状束等,研究表明其损伤常与患者的记忆、情绪、精神等改变有关.而在非颞叶癫痫患者中,是否存在颞叶联络纤维的改变尚不明确.本研究旨在初步探讨非颞叶癫痫患者颅脑白质连接纤维的改变,及其相关影响因素.
1.病例简介:男,23岁,因发热、头痛伴呕吐7d,意识障碍及频繁抽搐12+h入院.病前7d有受凉史,发热,测体温为38.2°C,头痛,为全头部持续性胀痛,非喷射性呕吐数次,均为胃内容物,无咖啡色样物质,曾就诊于当地医务所(具体诊治不详),症状消失.入院前12+h患者逐渐出现行为及精神异常,表现为胡言乱语,继之出现频繁抽搐,双眼向上凝视,双上肢屈曲,双下肢强直抽动,次,均为胃内容物,无咖啡色样物质,