From the view of Prevention Treatment of Disease and the angle of psychosomatic treatment,this article presents a whole new interpretation,which reflected in the practice of Treatment with Syndrome Differentiation in the progress of Psychosomatic Treatment.This new interpretation is including psychosomatic holism,connotation of Prevention Treatment of Disease and the importance of participation of both doctors and patients in Treatment with Syndrome Differentiation.More importantly this article brings up for the first time the concept of Treatment with Interpretation Differentiation.It emphasizes the directing function of the Culture-Cost-Benefit principle,and enriches the connotation of Treatment with Syndrome Differentiation and the clinical experience of psychocomatic treatment,by the view of the development of TCM theory.