【摘 要】
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Background:Combined p53 gene therapy(rAd-p53)and intra-arterial delivery of chemotherapeutic agents for treatment of oral squamous cell carcinoma were evaluated.Methods:Ninety nine patients with stage
【机 构】
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State Key Laboratory of Oral Disease,West China School of Stomatology,Sichuan University,Chengdu,P.R
【出 处】
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2014第八次全国口腔颌面-头颈肿瘤学术研讨会
论文部分内容阅读
Background:Combined p53 gene therapy(rAd-p53)and intra-arterial delivery of chemotherapeutic agents for treatment of oral squamous cell carcinoma were evaluated.Methods:Ninety nine patients with stage Ⅲ or Ⅳ oral carcinoma who had refused or were ineligible for surgery were enrolled in a phase Ⅱ placebo controlled,double blind,randomized phase Ⅱ clinical trial.They were randomly assigned to Group Ⅰ(n=35; intra-arterial infusion of rAd-p53 plus chemotherapy),Group Ⅱ(n=33; intra-arterial infusion of rAd-p53 plus placebo chemotherapy),or Group Ⅲ(n=31; intra-arterial infusion of placebo rAd-p53 plus chemotherapy).
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