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目的探讨多烯磷脂酰胆碱在老年肺结核患者中预防抗结核药物的肝功能损害的作用。方法选取老年肺结核患者80例,随机分为治疗组和对照组,各40例,均用异烟肼、利福平、吡嗪酰胺、乙胺丁醇四联强化抗结核方案治疗,治疗组加用多烯磷脂酰胆碱胶囊456 mg,po,tid。共观察8周。结果治疗组累计肝功能损害发生5例,对照组累计肝功能损害发生12例(P<0.05),在有肝功能损害的患者中,对照组ALT升高明显,与治疗组比较差异有统计学意义(P<0.05),对照组TBIL升高,治疗组无明显升高。结论多烯磷脂酰胆碱可以预防老年肺结核患者抗结核药所致肝损害的发生,减轻肝损害程度,而且安全可靠,值得临床推广应用。
Objective To investigate the effect of polyene phosphatidylcholine on prevention of hepatic dysfunction in elderly patients with pulmonary tuberculosis. Methods Eighty elderly pulmonary tuberculosis patients were selected and randomly divided into treatment group and control group, 40 cases in each group. All patients were treated with isoniazid, rifampin, pyrazinamide and ethambutol quadruple enhanced anti-TB regimen. With polyene phosphatidylcholine capsules 456 mg, po, tid. A total of 8 weeks observation. Results In the treatment group, cumulative liver damage occurred in 5 cases and in the control group, cumulative liver damage occurred in 12 cases (P <0.05). In patients with liver dysfunction, the ALT in the control group increased significantly compared with the treatment group Significance (P <0.05), the control group TBIL increased, no significant increase in the treatment group. Conclusion Polyene phosphatidylcholine can prevent liver damage caused by antituberculosis drugs in elderly patients with pulmonary tuberculosis, reduce the degree of liver damage, and is safe and reliable. It is worthy of clinical application.