High-quality whole-genome amplification(WGA)of individual cells is the primary step for characterizing the genetic information of single cells in biology and medicine1.
Existed sample preparation technologies for single cells genomics are operationally complex,expensive,and much coverage bias introduced despite recent advances,lagging behind in the impressive progres
Switching of DNA conformation by means of light as external stimulus has been a current research hotspot in the biological and chemical fields,but it is difficult for the further development due to no