【摘 要】
：
Background, Motivation and Objective Changes in stiffness occur in nearly every disorder ranging from cardiovascular diseases to cancer and neurodegeneration and occur across scales from the molecular
【机 构】
：
Department of Bioengineering, Imperial College London, London, United Kingdom;Mechanical Engineering
论文部分内容阅读
Background, Motivation and Objective Changes in stiffness occur in nearly every disorder ranging from cardiovascular diseases to cancer and neurodegeneration and occur across scales from the molecular to tissue level. Current ultrasound (US) palpation techniques use acoustic radiation force (ARF) as a stress source to deform the tissue and is the basis for a diverse range of US elasticity imaging technologies including acoustic radiation force impulse (ARFI) imaging and supersonic shear wave elasticity imaging. Yet ARF-based palpation methods can diagnose only a few diseases due to limitations of the stress source size, distribution, and depth. We propose a novel stress source that uses acoustic particles (e.g., microbubbles) driven by ultrasound to push against tissue surfaces deep in our body. This acoustic particle palpation (APP) method could reduce the stress source size, improve the distribution of stress, and enable deeper palpations.
其他文献
Background, Motivation and Objective Polarization-inverted multi-layer resonators are attractive for high order mode excitation and high power operation. In the ultrasonic microscope applications, n-f
Background, Motivation and Objective Large piezoelectricity in ScAlN film has received increasing interest in recent years. Elastic constant tensors of ScAlN films are required to design the SAW and B
Background, Motivation and Objective Focused Ultrasound (FUS) has a variety of potential uses, including therapeutic treatment of the gastrointestinal (GI) tract. Capsule endoscopy is already a key in
Background, Motivation and Objective For the development of image-guided high intensity ultrasound therapies, Capacitive Micro-machined Ultrasound Transducers (CMUTs) exhibit several advantages, such
Background, Motivation and Objective Estimating the motion of tissue in ultrasound is of paramount importance to elasticity imaging. There are a number of estimators available to estimate the local ax
Background, Motivation and Objective High intensity focused ultrasound (HIFU) transducers have been widely utilized for noninvasive therapeutic procedures. Piezoelectric ceramics with high depolarizat
Background, Motivation and Objective In traditional shear wave elasticity imaging (SWEI), shear wave velocity is measured away from the acoustic radiation force (ARF) axis. Instead, we measure the tim
Background, Motivation and Objective Applications such as High Intensity Focused Ultrasound (HIFU) conventionally use narrowband signals of high amplitude, which are then focused to a known point with
Background, Motivation and Objective Crawling waves sonoelastography (CWS) allows measuring viscoelastical properties in soft tissue at regions of interest. Recently, the Dominant Component Analysis A
Background, Motivation and Objective Crawling Wave (CrW) Sonoelastography is a technique that allows the estimation of elastic parameters through the calculation of the shear wave speed (SWS) in tissu