Non-phagocytic cell oxidase family of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase is the major sources of reactive oxygen species(ROS)in a number of non-phygocyfic cells.
Our previous study suggested that DNA-PKcs interacts with Snail1 which affect genomic instability, the sensitivity to DNA-damaging agents, and the migration of tumor cells by reciprocal regulation bet
The sources for cellular DNA damage include exposures to environmental chemicals and radiation as well as endogenous processes resulting from normal cellular metabolism.
Background: Radiation can cause tumorigenesis, with complex mechanism that has long been the research focus on oncology, radiobiology, and may be associated with oncogenes, cancer suppressor genes, an
The well-known classical pathway regulating autophagy involves serine/threonine kinase, mammalian target of rapamycin (mTOR).Generally, mTOR exists in a phosphorylated form in normal conditions and su
Understanding physical processes of rays interaction with matter and various conditions and factors affecting radiation biological effect are importment to obtain correct conclusion in radiation biolo
Cranial radiation therapy can induce cognitive decline.Impairments of hippocampal neurogenesis are thought to be a paramountly important mechanism underlying radiation-induced cognitive dysfunction.
Objective: To study the effects of catalase (CAT) overexpression on reactive oxygen species level and phenotype of malignant BERP35T-1 cells exposed upon 238Pu a-particles.