Soft-tissue adhesion on the electrosurgical instruments,usually occurring in the duration of the soft-tissue electrosurgical cutting,can induce many serious complications,such as failure of hemostasis and damage to the surrounding soft-tissue.And the charred soft-tissue on the instrument may result in non-uniform temperature distribution to deteriorate its cutting performance.To avoid adhesion of soft tissue on the surface of hightemperature electrosurgical instrument,i.e.anti-adhesion,is gradually becoming more necessary.Although several relatively effective anti-adhesion methods such as adding agents,spraying cooling water,and depositing films on the contact surface of the instruments,have been explored,they are also plagued with many problems including short-term residence,fabrication process complexity and low efficiency.Recently,slippery surface inspired by the pitcher plant Nepenthes has attracted considerable interests because of its remarkable selfcleaning and anti-adhesion capabilities.In this paper,we investigated the anti-adhesion effects of slippery surface on the stainless steel for soft-tissue at high temperature.Surface on the stainless steel was textured by photolithography-assisted chemical etching to hold the infused silicone oil with physiologically inert and hightemperature resistant.The anti-adhesion measurements for soft-tissue on the prepared slippery surface at high temperature indicated that soft-tissue adhesion force could be reduced approximately 80%at 250℃.Besides,the recycle testing of soft-tissue adhesion force and mass demonstrated the excellent stability of prepared slippery surface on the stainless surface.The results show that slippery surface is of great promise for soft-tissue anti-adhesion on the electrosurgical surfaces.