【摘 要】
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Having different phenotypic cellular states are ubiquitous in living cells.The existence and origin of multiple states of a cell in terms of its biochemical
【机 构】
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BeijingInternationalCenterforMathematicalResearch,Pekinguniversity
【出 处】
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2012China-Norway-Sweden Workshop on Computational Mathematic
论文部分内容阅读
Having different phenotypic cellular states are ubiquitous in living cells.The existence and origin of multiple states of a cell in terms of its biochemical basis is one of the fundamental questions in molecular biology.Beyond their existence,transit times between two such states in a single cell have great implications to cell differentiation,cellular development and microbial evolution.Measurements on stochastic gene expressions have shown that at the level of single-cell biochemistry,the chemical composition of major regulatory molecules,especially transcription factors,varies within a homogeneous cell population.A phenotypic cellular state can be precisely defined experimentally by a modal-value of the probability distribution over a ”chemispace”.
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