Little information is available about the risk of progression of seemingly benign adrenocortical hyperplasias to arcinomatous conditions.Using in silico approaches of digitally archived tissue sections, we have compared the nuclear morphometric parameters to assess nuclear asymmetry as an index for nuclear atypia.Four groups of nuclei were used for the current study:spongiocytes and compact cells obtained from ACTH-independent macronodular hyperplasia, that were hypothesized to be high risk for nuclear asymmetry and PPNAD and micronodular adrenocortical hyperplasia samples were used as intemal controis.