【摘 要】
：
引言/目的 组织蛋白酶B (CTSB)是一种存在于线粒体内的半胱氨酸蛋白酶,具有分解细胞内蛋白的功能,在细胞凋亡过程中起到重要作用.本实验室的前期研究结果证实,CTSB在绵羊卵丘
【机 构】
：
河北农业大学保定071000河北农业大学保定071000;河北省牛羊胚胎工程技术研究中心保定071000
【出 处】
：
中国畜牧兽医学会动物繁殖学分会第十七届学术研讨会
论文部分内容阅读
引言/目的 组织蛋白酶B (CTSB)是一种存在于线粒体内的半胱氨酸蛋白酶,具有分解细胞内蛋白的功能,在细胞凋亡过程中起到重要作用.本实验室的前期研究结果证实,CTSB在绵羊卵丘细胞中的基因表达水平以及在卵丘卵母细胞复合体(COCs)中的酶活性水平,与卵母细胞发育能力呈负相关[1];E-64作为一种不可逆的组织蛋白酶抑制剂,将其添加到成熟液中可以提高绵羊卵母细胞的发育能力[1][2].为此,有必要进一步开展E-64对绵羊卵母细胞内组织蛋白酶B活性影响的研究,这对阐明E-64提高绵羊卵母细胞发育能力的机制具有重要意义.
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