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Background: Liver resection remains the gold standard in the treatment of colorectal metastases.Aim: to evaluate if there is any difference in clinical characteristics and outcome in the last ten years compared to previously, in resected patients for colorectal metastases.Methods: Clinico-pathologic characteristics were compared between 342 resected patients before 1999 and 310 resected patients after 2000.Results: There was no difference in term of sex, age, mean tumor diameter and synchronous vs metachronous between the 2 groups.The median number ofresected metastases/patient was significantly increased after 2000 (1.7±1 vs 2.4±2, respectively).Postoperative mortality was similar (1.2 vs 2.3%), even if morbidity increased from 19% up to 27.1%.There was a tendency to perform less number of major hepatectomies after 2000 (61.7% vs 55.2%, respectively).Blood transfusion was required in 44.7% of patients in the first group, and in only 23.9% after 2000.Postoperative hospital stay decreased significantly from 12.7±11 days to 9.5±13.The 5-year overall survival increased from 37% up to 48% after 2000 (p<0.001) The 5-year disease-free survivals were 33% and 36%, respectively (p=n.s.).Among patients with single metastases, the 5-year overall survival did not change significantly between the two periods (43% vs 46%); while 5-year survival increased significantly from 28% up to 47% in the second period, among patients with multiple metastases (p<0.001).Finally, the number of usefulness laparotomy decreased significantly from 47 (13.7%) before 2000, to 29 (9.4%) after 2000 Conclusions: Nethertheless an increased number of advanced patients were operated on after 2000, there was a tendency to perform a parenchimalsparing resection and there was a significantly improvements in overall survival rate in the last decade, in particular among patients with multiple metastases probably due to the efficacy of new adjuvant chemotherapy.