【摘 要】
:
Innate immune cells such as dendritic cells can be profoundly impacted in advanced cancers.This can lead to their dysfunctional activity and consequently compromised anti-tumor immunity.Alternatively,
【机 构】
:
Icahn Institute of Medicine at Mount Sinai,USA
【出 处】
:
2016年国际树突状细胞研讨会(The 14th International Symposium on Dendriti
论文部分内容阅读
Innate immune cells such as dendritic cells can be profoundly impacted in advanced cancers.This can lead to their dysfunctional activity and consequently compromised anti-tumor immunity.Alternatively,the tumor microenvironment can support DC activation through a number of mechanisms that involve their local activation through the production of tumor associated nucleic acids.
其他文献
Econdary lymphoid organs(SLO)are the primary locations for initiation of immune responses.During embryonic lymphogenesis,lymphoid tissue-inducer cells(LTi)mediate the initial development of these stru
Despite their great success,we understand little about how effective vaccines stimulate protective immune responses.Two recent developments promise to yield such understanding:the appreciation of the
Macrophages represent a diverse set of phagocytic cells distributed in the whole body.They play a central role in a variety of biological events including host defence against pathogens,tissue remodel
In contrast to conventional T cells that recognize peptides on MHC proteins,CD1 molecules present lipid antigens to T lymphocytes.The abundant expression of CD1a hallmarks Langerhans cells in the skin
We study the human system to address fundamental questions in the context of the immune response to different classes of antigens,including microbial pathogens and self-antigens,to gain insights into
Systemic Lupus Erythematosus(SLE)is a systemic autoimmune disease characterized by a breakdown of tolerance to nuclear antigens and the development of DNA and RNA-containing immune complexes(IC).Genom
Plasmacytoid dendritic cells(pDC)are major producers of type Ⅰ interferons(IFN-I)in response to recognition of pathogen-derived nucleic acid molecules by endosomal toll-like receptors.Involvement of p
Dendritic cells(DCs)and macrophages play important roles in maintaining intestinal homeostasis.However,the molecular mechanisms that regulate the differentiation and responses of intestinal DCs and ma
Isoforms are alternatively spliced forms of mRNA that are transcribed from the same gene but differ in the exons that are included in the mRNA transcript.This greatly increases the diversity of protei
Conventional chemotherapeutics and targeted antineoplastic agents have been developed based on the simplistic notion that cancer constitutes a cell-autonomous genetic or epigenetic disease.Nonetheless