聚丙烯酰胺(PAM)的毒性成分系其单体丙烯酰胺(AM)。AM是一种神经毒剂,主要损害部位在周围神经系。坐骨神经,特别是其末稍部分蓄积量较它处高。用透射电镜技术观察了饲服国产PAM(含AM0.53％)的大白鼠(体重350克左右)7只和小白鼠3只的坐骨神经的股后段。其结果如下:①线粒体异常呈多样性,以低电子密度肿胀(水肿)为多见。有的整个基质室肿胀,成规则的球形或卵园形;有的为局灶性肿胀,使线粒体成畸 Polyacrylamide (PAM) is a toxic component of its monomer acrylamide (AM). AM is a nerve agent, the main damage in the peripheral nervous system. Sciatic nerve, especially the last part of its accumulation of higher than it. Transmission electron microscopy was used to observe the posterior segment of the sciatic nerve fed 7 domestic rats (AM0.53%) containing rats (weighing about 350 g) and 3 mice. The results are as follows: ① mitochondrial abnormalities were diverse to low electron density swelling (edema) is more common. Some of the entire basal body swollen, into a regular spherical or egg-shaped garden; some for focal swelling, so that mitochondrial abnormalities