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5. Synthetic Studies on Ecteinascidin 743

Synthetic Studies on Ecteinascidin 743

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：a67273271

【摘 要】

：

The key intermediate ofecteinascidin 743[1] was efficiently synthesized from sesamol in 11 steps and 25％ overall yield.The key steps are a Noyori reduction, a diastereoselective Claisen rearrangement,

【作 者】

：

Eiji Yoshida Tatsuya Toma Satoshi Yokoshima Tohru Fukuvama 

【机 构】

：

Graduate School of Pharmaceutical Sciences,The University of Tokyo,7-3-1 Hongo,Bunkyo-ku,Tokyo 113-0

【出 处】

：

The 24th International Society of Heterocyclic Chemistry Con

【发表日期】

：

2013年4期

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论文部分内容阅读

The key intermediate ofecteinascidin 743[1] was efficiently synthesized from sesamol in 11 steps and 25％ overall yield.The key steps are a Noyori reduction, a diastereoselective Claisen rearrangement,[2] and cyclization of an acyliminium salt.

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